The Molecules of HIV

Note: this site last updated in 2006

HIV-1 and HIV-2

An article from "The Molecules of HIV" (c) Dan Stowell
www.mcld.co.uk/hiv

By 1985 HIV was a recognised retrovirus, but then it was observed that the few AIDS cases in West Africa were associated with a different virus from what had become known as HIV. The new virus was called HIV-2.

Are they "the same" virus? Clearly they're related (they have similar effects and almost exactly the same set of genes) - but in fact HIV-2 is strictly more like certain types of simian immunodeficiency virus (SIV) than it is like HIV-1. Both HIV-2 and SIV carry an extra gene not found in HIV-1, which encodes Viral protein X. And comparing the viral proteins of HIV-2 and SIV, only subtle differences in molecular sizes can differentiate them.

All three - HIV-1, HIV-2, and SIV - seem to have developed from a common ancestor.

HIV-1 is more pathogenic than HIV-2. The reason seems simply that once it's integrated into a cell, it is faster at producing new virus particles.

See also: The HIV genome

Relevant journal articles:

  • Lower human immunodeficiency virus (HIV) type 2 viral load reflects the difference in pathogenicity of HIV-1 and HIV-2 Popper SJ, Sarr AD, Travers KU, Gueye-Ndiaye A, Mboup S, Essex ME, Kanki PJ, Journal of Infectious Diseases, 180 (4): 1116-1121 OCT 1999

Written by
Dan Stowell
(©2002-2006)

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