The Molecules of HIV
Note: this site last updated in 2006

nef

An article from "The Molecules of HIV" (c) Dan Stowell
www.mcld.co.uk/hiv
The "negative replication factor" ("nef") gene encodes a protein which hangs around in the cytoplasm of the cell, and retards HIV replication. Possibly it does this by modifying cellular proteins that regulate the initiation of transcription - that is, it affects the proteins which tell the cell whether or not to make RNA copies of the DNA code. Facts:
  • nef protein size: 27 kD

Written by
Dan Stowell
(©2002-2006)

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