The Molecules of HIV

Note: this site last updated in 2006

preintegration complex

An article from "The Molecules of HIV" (c) Dan Stowell
www.mcld.co.uk/hiv

The HIV preintegration complex is essentially the viral core (i.e. two strands of RNA, with some HIV proteins), released into the cell, to which cellular proteins have attached. (HIV-1 preintegration complexes have been shown not to have capsid protein in, so the capsid must presumably degrade during the formation of the preintegration complex.)

The preintegration complex is the assemblage which carries out HIV reverse transcription and initiates integration. The HIV preintegration complex (Bukrinsky et al., 1993) consists of the newly synthesized DNA, nucleocapsid protein, structural protein p6, the accessory protein Vpr, integrase (IN) and several copies of matrix protein (MA).

Written by
Dan Stowell
(©2002-2006)

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